Assessment of Lipoprotein (a) In Blood Samples of Sudanese Diabetic Patients Correlated With Glycosylated Heamoglobin

Abstract

The Sudanese diabetic patients may have high frequency of dyslipidaemia, which contribute to accelerated coronary atherosclerosis. This study aims to assess Lp (a) and HbA1C in blood samples of Sudanese diabetic patients. In this cross-sectional prospective study, blood samples of 150 Sudanese diabetic patients were collected. Diabetic patients were informed and consented to participate in this study. Results of 100 non-diabetics were compared with patient's results. Chromatographic spectrophotometric ion-exchange method and turbidimetric spectrophotometric method were applied to measure HbA1C and Lp (a), respectively. Results were analyzed statistically using student-'t' test, compared as mean and standard deviation and considered significant when (P <0.05). In this study Lp (a), and HbA1C mean levels were increased significantly in diabetic patients when compared to control (P<0.01). All diabetic patients participated in this study had Lp (a) concentrations >30mg/dl exceeding the cut-off value of Lp (a). However, Lp (a) concentration at the level ?100mg/dl represent 33.3% of the total diabetic cases. This indicates a high risk for those patients. Greater than 40% of diabetic patients were having HbA1C level >9.0%, hence they were at increased risk of cardiovascular complications because they were having poor glycaemic control. These results conclude addition of Lp (a) to the routine lipid profile to assess cardiovascular risk in diabetic patients which may enhance management of diabetes mellitus.