Assessment of Complete Blood Count of Chronic Renal Failure Patients Under Hemodialysis

Abstract

This study aimed to detect the effects of renal hemodialysis on some blood parameters in chronic renal failure patients using complete blood count (CBC) Hb, HCT, RBC, MCV, MCH ,MCHC, WBC and blood platelets. The patients were divided into two groups according to their age. Group (A) patients bellow 16 years, group (B) patients with age ranged between 40-55 years. Eighty chronic renal failure patients under hemodialysis attending Khartoum North Dialysis Center, Selma Dialysis Center and Soba Hospital, were enrolled (group A). Twenty control individuals were selected for the study. Fifty patients with chronic renal failure under hemodialysis attending Alnaw Hospital were selected for the study, their age ranged between 40-55 years ( Group B). Twenty individuals who were matched as a control. A specimen of 2.5 ml of blood was collected from each patient in EDTA container. Automated hematological analyzer (Sysmex KX -21N) was used to measure the parameters. The results showed a significant decrease in Hb, HCT and RBC in both groups compared to control group. Hb of group A is 9.6 ±2.2 g/ dl and that of control is 13.4±0.89 g/dl . In group B, Hb is 8.8 ±2.1 g/ dl compared to 15.1± 1.5 g/dl of control group. MCV, MCH and MCHC of group A significantly decreased compared to control .MCV = 83.1 ± 5.4 fl , MCH =27.3±2.2 pg, MCHC =32.7±1.4 g/dl. No significant change was observed in MCV,MCH and MCHC of group (B). TWBC of group B increased insignificantly, from 5.00±1.0 cell /cmm (control level ) to 6.4± 2.6 cell / cmm. Platelets of group B decreased significantly from control level but within range of 314.3 ± 52.6 cell/ cmm to 209.4±79.2 cell/cmm. In conclusion CRF patients under hemodialysis are at risk of anemia, thrombocytopenia and bleeding tendency.