Assessment of Lipids Profile in Hyperthyroidism Sudanese Patients in North Kordofan State, Sudan

Abstract

The objective of this study was to find out possible relationship between thyroid hormones and lipids profile levels in Elobeid city, North Kordofan State, during the period from March 2011 to March 2012. A total of 250 subjects were selected for this study. Out of 250 subjects, 150 were patients, Female to Male ratio was 2.75: 1.0 (100 patients were hyperthyroidism before treatment (new cases), 50 patients were currently under treatment (Evert hyperthyroidism) and 100 were apparently healthy individuals (ascertained as controls). Thyroid hormones were measured using ELISA technique. For cholesterol, triglycerides using enzymatic spectrophotometeric method and precipitation enzymatic method for HDL-C and LDL-C.T3 and T4 were significantly increased in new cases (3.9 ± 1.1 p-value <0.00) and (16.9 ±3.1 p-value <0.00) compared with control group (1.08 ± 0.4) and (8.07 ± 1.6) for T3 and T4, respectively.TSH was significantly reduced (0.05 ± 0.06 p-value <0.00) compared with control (2.6 ± 0.17). In patients under treatment T3, T4 and TSH were not altered in comparison with control p-value (0.272, 0.633 and 0.061), respectively. Lipids profile, the total Cholesterol, LDL-C and HDL-C were significantly decreased (107± 10.9 p-values <0.00, (46.6 ± 10.4 p-values <0.039), and (35.6 ± 3.3 p-values <0.00) in compression with control groups (154 ± 67), (52 ± 7.2) and (79.3±12.9) for lipds profile respectivly. There was negative correlation between the level of lipids profile and thyroid hormones level (T3 and T4) and positively correlated with the triglycerides. It was concluded that T3 and T4, as well as triglycerides, are elevated in hyperthyroidism, while cholesterol is decreased.