In-Use Stability Study of Paracetamol Syrup

Abstract

This research is aimed to study the in-use stability of paracetamol, two sample where taken one local and the other was imported. Four bottles (from the same batch) from each sample were taken and undergo the same condition, any drug in-use could be effected by . The samples undergone the same condition any drug in-use undergo such as 40ᵒC temperature humidity 75% and 30ᵒC temperature humidity 65% . Then the drug was analyzed for month (0time,15days, 30days). The contents of paracetamol were measured by HPLC and the result was too close during the time of study. IR spectroscopy was used to know the effect of condition of the functional group. Another device can be used such as UV\VIS spectroscopy, NMR spectroscopy and MASS spectroscopy. The changes were minor because the stability of product was high.