Serum Level of Vitamin D among Females with Sickle Cell Anemic Patientsin Khartoum State

Abstract

Vitamin D deficiency is now recognized as one of the most common nutritional conditions among persons with Sickle Cell Disease (SCD).The motivation for better understanding the magnitude of vitamin D deficiency among populations with SCD. This is case control study conducted during the period from February to June2016, patients are chosen from Gaafer Bin Aoufto determine the level of vitamin D among Sudanese female with sickle cell disease, the level of vitamin D was estimated by using ELISA. The study include 80 subject, 50 sickle cell anemic patients, (40 malignant + 10 benign) and 30 of them were apparently healthy individuals as control group. Statistical analysis was done by using SPSS. And the result showed a significant decrease in means of vitamin D in sickle cell anemic patients (27.07±15.95) when compared to control group (35.18±12.09) with p-value 0.020.The study hasrevealed a significant negative correlation between vitamin D level and age(r=ˉ0.445, p-value=0.005).the result has revealed there was no correlation between vitamin D level and duration of treatment(r=0.107, p-value 0.694). It is concluded that the serum level of vitamin D is decreased in patients with sickle cell disease, there were no relationship between the level of vitamin D and duration of treatment and the increasing of age of sickle cell anemic patients has associated with decreasing of vitamin D level.