Serum Level of Anti-mullerian Hormone among Sudanese Females with Sickle Cell Anemia in Khartoum and Western Kordofan States

Abstract

Sickle cell anemia is widely spread throughout the world and the effects of it on human health are serious. It is a group of genetically passed down blood disorders. It results in an abnormality in the oxygen-carrying protein hemoglobin found in red blood cells. This is a case control study was done inJaaferEbinOuf hospital in Khartoum state and Hejleej hospital in Western state during March to December 2016, to evaluate serum Anti-mullerian Hormone “AMH” level among Sudanese females with sickle cell anemia. Eighty Sudanese females 50 females with sickle cell disease were selected as test group (40 females with sickle cell anemia & 10 females with sickle cell trait) and 30 healthy females without sickle cell disease as control group”age was matched. blood specimen were collected from both groups and serum anti-mullerian hormone (AMH) is determined by using Mindary MR-96A autoanalyzer. The statistical analysis was done by using SPSS computer program, the results showed that there was insignificant difference in mean concentration of serum AMH of females with sickle cell disease)0.697±0.449)in comparison with females without sickle cell disease(0.684±0.226(, with p.value of (0.862) The result showed there was no correlation between the AMH concentration and age with (r=0.001,p-value =0.993). Also the results showed that there were no correlation between the AMH concentration and duration of hydroxyurea treatment with)r=0.185, p-value =0.510). The study results revealed that that sickle cell anemia doesn’t affect serum AMH level in females. Also there were no correlation between the AMH concentration, age and duration ofhydroxyurea treatment.