Evaluation of Serum Lipid Profile among Sudanese Patients with Hyper or Hypothyroidism In Khartoum State

Abstract

A case control study conducted during the period from April to October 2016, to evaluate serum lipid profile among Sudanese patients with thyroid diseases (hyperthyroidism and hypothyroidism) in Khartoum state. The study group included 60 patients 30 hyperthyroidism, and 30 were hypothyroidismand 30 were apparently healthy individuals as control group (match age and sex). Aspectrophotometer was used for measurement of lipid profile (total cholesterol, triglycerides, LDL-c and HDL-c). ELISA reader was used for hormones measurements (total T4, T3) and TSH and program software SPSS was used for analysis the results. The results showed that thyroid disorders are common among female (85%) while male was (15%). Also most common among age (36-45) years (in hyperthyroidism (53%), hypothyroidism (57%). In hyperthyroidism total cholesterol, triglycerides and LDL-c were significantly increased when compared to a control group while HDL-c was significantly decreased, as in table (4-2) total cholesterol (mean± SD: 187 ±39 mg/dl versus 136.8±20.9mg/dl p.value = 0.00), triglycerides (mean± SD:164.6 ±69.6 mg/dl versus 118±37.4mg/dl, p.value =0.00), LDL-c (mean± SD:126.7 ±43.9 mg/dlversus 80.4±18.9 mg/dl,p.value = 0.00) and HDL-c (mean± SD: 27.9 ±10.1mg/dl versus 32.7±6.7 mg/dl,p.value =0.00). In hypothyroidism the level of total cholesterol, triglycerides, and LDL-c were significant increased (mean± SD: 190.6 ±48.1mg/dl versus 136.8 ± 20.9 mg/dl p.value 0.00) (mean± SD: 182 ±92.5 mg/dl versus 118 ±37.4mg/dl,p.value = 0.00) LDL-c (mean± SD: 129.2 ±49.9 mg/dl versus 80.4±18.9mg/dl, p.value = 0.00), HDL-c was signifsicant decreased (mean± SD: 24.9± 8.3mg/dl versus 32.7 ±6.7mg/dl, p.value = 0.00). Correlation studies were showed significant positive correlation between TSH and total cholesterol, triglycerides and LDL-c(r=0.434, 0.252, and 0.404. p.value= 0.00, 0.025, 0.00) respectively.While a significant negative correlation with HDL-c (r=-0.252, p.value=0.024). The study concluded that there were significant increased in lipid profile (total cholesterol, LDL-c and triglycerides) in both hyperthyroidism and hypothyroidism in compared to control subject, while HDL-c was significant decreased in both hyperthyroidism and hypothyroidism in compared to control. Also there were significant positive correlation between TSH level and total cholesterol, triglycerides, LDL-c and significant negative correlation with HDL-c.