Abstract:
In the present work fifty six a new α, β - unsaturated carbonyl compounds
and their cyclization reactions with varieties reagent (hydrazine derivatives,
hydroxylamine and thio urea) pyrazole, isoxazole and thiopyrimidine
derivatives were prepared. A process of the preparation of α, β – unsaturated
carbonyl compounds by coupling to diazotized a p-aminoacetophenone with
1.3 di carbonyl compounds (ethyl acetoacetate, acetyl acetone, bezoylacetone
and dimedone) in presence sodium acetate and ethanol (C-N) bond was
formed. Some of the resultant compounds reacted with hydrazine derivatives
lead to cyclized to the pyrazole derivatives and condensed with aromatic
aldehyde give the synthesis α, β – unsaturated carbonyl. Later were prepared
directly from some resultant of the coupling with dimedone in presence basic
media sodium hydroxide at room temperature . The reaction progress for all
synthesized compounds was checked by (TLC) technique , meting point, and
yield percentage. The structure of synthesized compounds were confirmed by
spectroscopic instruments IR, some of synthesized compound were confirmed
by UV, IH-NMR, 13C-NMR, MS.
