Assessment of Gamma Camera Based 99mTc-DTPA Glomerular Filtration Rate Using Inoue Method

Abstract

Glomerular filtration rate (GFR) is generally accepted as the most representative parameter of renal function. It is relatively constant under standard conditions. GFR being reduced prior to the onset of symptoms of renal failure, its assessment enables earlier diagnosis and therapeutic interventions in patients at risk. Various methods are available for the measurement of GFR, including the inulin continuous perfusion method, methods related to creatinine clearance, methods using prediction equation, plasma radioactivity clearance method, and gamma camera methods. The aim of this study was to assess the gamma camera based of 99mTc-DTPA glomerular filtration rate using Inoue method. In this study, seventy-five subjects were studied, (50.7% men; 49.3% women), included patients with renal diseases, as well as potential donor for renalGlomerular filtration rate (GFR) is generally accepted as the most representative parameter of renal function. It is relatively constant under standard conditions. GFR being reduced prior to the onset of symptoms of renal failure, its assessment enables earlier diagnosis and therapeutic interventions in patients at risk. Various methods are available for the measurement of GFR, including the inulin continuous perfusion method, methods related to creatinine clearance, methods using prediction equation, plasma radioactivity clearance method, and gamma camera methods. The aim of this study was to assess the gamma camera based of 99mTc-DTPA glomerular filtration rate using Inoue method. In this study, seventy-five subjects were studied, (50.7% men; 49.3% women), included patients with renal diseases, as well as potential donor for renalfunction of any severity. A modification to the Inoue method was recommended which may result in a marked improvement in its result that could lead to an expanding in the usefulness of the method