Abstract:
Hemostasis is intimately related to liver function, because most coagulation factors are synthesized by liver parenchymal cells, and the liver's reticuloendothelial system serves an important role in the clearance of activation products. Theextent of coagulation abnormalities depends upon the degree of disturbed liver function. The aim of this study tomeasure Prothrombin time (PT) and Partial Thromboplastin Time (APTT) in liver disease patients attending Omdurman Teaching Hospital.
This is a case control study was conducted in Omdurman Teaching Hospitalto evaluate the effect of liver disease on prothrombintime(PT) andPartial thromboplastin time(APTT). Data were collected using self-administered pre-coded questionnaire which was specifically designed to obtain information including age, sex, duration of the disease and other information.
Blood sample was collected from fifty patients with liver diseasesand other fifty samples were collected from apparently healthy individuals as control group. Five ml of venous blood was collected from each subject after filling the questionnaire and placed in plastic container containing 250ml tri sodium citrate as anticoagulantthen was centrifuge for preparation of platelets poor plasma (PPP). The PPP was tested for the PT,APTT and INR by using the coagulometer instrument (Clot).The results were analyzed by Independent T test, one way a nova test and correlation test using statistical package of social sciences (SPSS version 11.5).
The results revealed that there was significant increase in PT level in case (16.0 ±4.6sec) compare to control group (12.4±0.7sec) (P. value .000), INR result in case (1.41±0.4) compare to control group (1.08± 0.07) (P. value .000) and APTT level in case (39.9±7.5sec) compare to control group (31.3±1.7sec) (P. value .000).
The study also revealed there a significant difference in PT,APTT and INR results when comparing between different liver diseases in which there was increase in PT/sec, APTT/sec and INR results in hepatic encephalopathy when compared with other liver diseases, also there was increase in APTT/sec in HCC and LC when compared with other liver disease. There are no any changes in PT, APTT and INR related to gender, age and duration of disease.
The study concluded that liver diseases have significant effect on increasing PT, APTT and INR in patients with liver diseases.
