Seroprevalence of Cytomegalovirus Infection among Leukemic Patients in Khartoum State

Abstract

This study was amid to determine the seroprevalence of human cytomegalovirus (HCMV) among leukemic patients attending at Radiation Isotope-center-Khartoum (RICK )from April toAugust 2015 A total of 90 Subjects were included 70 Leukemic Patients and 20 of them were hematological healthy (Control group) Personal and clinical data were collected by questionnaire after verbal consent, serum samples were collected, tested for CMV IgG&IgM using enzyme-linked immune sorbent assay (ELISA). Out of the 70 leukemic patients 68/70(75.6%) were positive for CMV IgG while 11/70 (12.2%) of them were positive for CMV IgM. All the 20 control group (100%) were negative for CMV IgM and 13/20 (14.4%) were IgG positive. This study had also tried to find a relationship between the possible risk factors of age, gender and type of leukemia on CMV IgM/IgG antibodies The results showed that the prevalence of cytomegalovirus (CMV) according to the type of leukemia was high in case of chronic myeloid leukemia CML. the IgG positive patients was 42 (60%) and the IgM was 6 (8.5%), with no significant difference between types of leukemia. The results furtherly showed that 57.8% of male had IgG & 10% IgM while the 32% of female had IgG & 2.2% had IgM . This was no significant effect of age. The highest prevalence of CMV was in children less than 20 year. This Study concluded that there was significant correlation between leukemia and human cytomegalovirus (HCMV).