Evaluation of the Effect of Thyroid Dysfunction on Complete Blood Cell Count on Sudanese Patients in Khartoum State

Abstract

A descriptive cross- sectional hospital –based study was conducted from (January 2015 to April 2015).100 blood sample were taken from Sudanese thyroid disease patients (35 patients were selected 35 with hyperthyroidism 35 with hypothyroidism) in Military hospital addition to 30 apparently healthy person were selected as controlgroup. The study group were a selected with age range from 20 -60 years. 3ml of venous blood was withdrawn, From each participant , placed in a test tube containing EDTA. Complete blood count were determined using an automated cell counter (Sysmx Kx.N21).The results were analyzed by Stastiscal Package of Social Science (SPSS) version16.The result Showed that percent of female with hyperthyroidism and hypothyroidism higher than percent of male .Significant decrease in Hemoglobin, Hematocrit , Mean cell Hemoglobin in patients with hyperthyroidism & hypothyroidism compared to control group (P.value<0.05). Red Blood Cell showed significant decrease in hypothyroidism patients when compared with control group(P.Value<0.05).Significant decrease in Mean Cell Volume in hyperthyroidism group when compared with control(P.value< 0.05).No significant difference were noted for White Blood Cell count , platelets count and Mean cell Hemoglobin Concentration in patients with hyperthyroidism and hypothyroidism ( P.Value>0.05). From obtained dataThyroid dysfunctions have direct effect on most red blood cells indices and this change should be considered by medical care provider. These finding suggest that thyroid hormone has effect on red cell count and red cell indices which can cause different type of anemia.