Measurement of Prothrombin Time and Activated Partial Thromboplastin Time of Sudanese Smokers in Khartoum State

Abstract

This is a case control study, was done in khartoum state in the period from april to september 2014.The aim of this studyis to determine some of the haemostatic parameters (Prothrombin Time(PT) and Activated Partial Thromboplastin Time(APTT), among Sudanese tobacco smokers to determine the effect of smoking on PT and APTT.One hundred and fifty blood samples were collected , 100 samples as a case group (smokers), and 50 samples as a control group (non-smokers). Platelet Poor Plasma were obtained form the blood samples to measure the PT and APTT using coagulometer . The result revealed that the mean of PT was 18.2±3.2 seconds among the case group and 13.1±1.5 seconds for the control group was statistically significant (P <0.05), while APTT was 33.4± 3.5 seconds and 30.8±2.1 seconds for case and control group respectively, was statistically insignificant (P > 0.05). Also the result showed that there is no significant differences regarding to PT and APTT when compared with the duration of smoking and the number of cigarette smoked per day. On conclusion there was a significant prolongation of PT among the case group (smokers) and the APTT were not affected.