Assessment of the Plasma Levels of The Liver Enzymes among Sudanese with Type 2 Diabete Mellitus Associated with Myocardial Infraction in Khartoum State

Abstract

A cross sectional study conducted during the period from March 2012 to August 2012 to determine and to evaluate the serum levels of liver enzymes (AST, ALT, ALP) in Sudanese with type 2 diabetes mellitus and myocardial infraction. One hundred Sudanese with type 2 diabetes mellitus and myocardial infraction were selected as a test group from Sudan heart center and Alsab hospital in Khartoum state , Sudan. The test group was compared with a control group, which included 50 apparently healthy volunteers. Blood speciems were from both groups, and the serum levels of liver enzymes , in addition to glycated hemoglobin (HBA1C) were determined. Age and gender of test group were matched with the control group. Serum level of liver enzymes and glycated hemoglobin were measured using spectrophotometric methods . Statistical pakage for Social Science (SPSS version 11.5) computer software was used for data analysis. The results of this study indicate a significantly raised means of the serum level of AST ,ALT, ALP of the test group when compared with the control group. The result of this study indicate also significant elevation of the means of AST, ALT and ALP in smoker patients when compared to non smoker one. This study shows insignificant difference of the means levels of AST, ALT and ALP in diabetic with hypertension when compared to those without hypertension. This study shows insignificant difference of the means levels of AST, ALT in diabetic with hyperlipidemia when compared to those without hyperlipidemia, where as ALP show significant difference between hyperlipidemic and without hyperlipidemic patients. The current study shows insignificant difference of the means levels of AST, ALT, ALP in diabetic with renal disease when compared to those without renal disease. The result of the study shows significant raised in the means of AST, ALT in diabetic patients with liver disease when compared with those free from liver disease, where as there insignificant difference in ALP in diabetic with liver disease compared to those without liver disease. The result of the current study indicate significant correlation between HBA1c and the AST and ALT, where as there insignificant positive correlation between HBA1c and ALP. Also shows significant positive correlations between age and ALT, ALP, where as there was insignificant correlation between age and AST.