Abstract:
The introductory chapter of this thesis outlines multicomponent reactions
and describes in detail the chemistry of the Mannich reaction. The final section
of the introduction deals with chemical informatics
Ten compounds of β-aminoacetophenone derivatives were synthesized by
the condensation of ketone (acetophenone or p-bromoacetophenone) with
different aromatic amines and benzaldehyde; general preparative method,
ACD/lab programmer method and Swiss target prediction method for
synthesized compounds were also described.
The results and discussion focused on application of ACD/Lab programmer
in calculation and correlation of structure properties of the some β-amino
acetophenone derivatives, elucidation of the structures of the synthesis
compounds
by various spectroscopic methods (IR and 1 HNMR) calculations
of the percentage, Rf value and the melting point of the synthesized compounds.
