Abstract:
End stage renal disease (ESRD) is a major health problem in Sudan
which is stage five of chronic renal failure leading to many
complications. Patients need to dialysis as a treatment to survive.
Haemodialysis leading to platelets abnormalities (chronic platelets
activation) while the platelets play a major role in haemostasis and
they are natural source of growth factors which are play a significant
role in repair and regeneration of connective tissues in healthy
individuals.
This analytical descriptive cross sectional case-control study was
conducted in Al-Ribat Hospital during the period from March to May
2014.The aim of the study was to determine the changes in platelets
activity by measuring platelets count and platelets indices
(MPV,PDW, and P-LCR) among Sudanese End Stage Renal Disease
Patients attending Al-Ribat Hospital in the renal dialysis unit.
Eighty four blood samples were collected from the patients with end
stage renal disease (ESRD) and fifty blood samples were collected
from apparently healthy (controls) individuals. 2.5 ml of blood was
collected from each patient and control , automated haematological
analyzer ( Sysmex KX-21N) was used to measure platelets count,
MPV, PDW, P-LCR. Informative data of age and gender , were
collected using a questionnaire during the period of March to May
2014.
Firstly, the Age in this study was divided to three groups (20-40),
(40-60), (60-80) years.
The study results revealed that platelets count was significant
decreased and MPV was significant elevated on the end stage renal
disease patients. The mean value of patients with end stage renal
disease of platelets count (185.25± SD) and mean value of MPV
(13.02± SD) respectively .The mean value of Platelets count (274.86±
SD) and mean value of MPV (9.36± SD) in control group
respectively.
The study concluded that there was a significant effectiveness of
platelets count and MPV on ESRD patients , the other parameters
(PDW and P-LCR) have no significant effectiveness on ESRD
patients.
Also, no significant effectiveness of gender on platelets count, MPV,
PDW, and P-LCR of end stage renal disease patients, and there was
no significant effectiveness of age on PDW and P-LCR of end stage
renal disease patients but there was an age effectiveness on platelets
count ( inverse relation) and also there was an age effectiveness on
MPV (direct relation) of end stage renal disease patients
