Evaluation of Complete Blood Count in Sudanes Patients with Systemic Lupus Erythomatosus ( SLE) in Khartoum State

Abstract

This is a case control studyaimed to evaluate complete blood count in systemic lupus erythomatosus( SLE) , conducted during the period of April to November 2014at Ommdurman Military Hospital included 50 femalepatients already diagnosed with SLEwith age ranged between 18-62years, and 50 apparently healthy females as control with matched age range were selected for this study .A questionnaire was designed to obtain basic and clinical data of patients after explanating of objectives for them,2.5 ml of venous blood was collected from each participant ,for each sample of blood CBC parameters were measured using Sysmex (XT 2000 i) automated analyzer, data were analyzed using the SPSS computer programme. A significant decrease was observed in SLE patient’s Hb(11.2 g/dl ± 1.9)VS control (4.2×106/μl±0.6)VS(4.6 (12.7g/dl ± 106/μl 0.5) ± 1.1), , RBCs PCV count (34.2% ± 9.1)VS(38.5% ± 3.8) ,MCH (26.8/fl ± 2.9)VS(27.9/fl± 2.2) , Neutrophils(4.1×103/μl ± 2.1)VS(3.0×103/μl ± 1.1 , Eosinophils (0.1×103/μl ± 0.1)VS(0.2×103/μl ± 0.1) and Basophils(0.0 ×103/μl ± 0.0) VS(0.0×103/μl ± 0.0 ) with P.value less than 0.05 .No 5difference in MCV, MCHC ,Platelets count, WBC,s count,lymphocytes and monocytes differential count in SLE patients compared to control group with P.value > 0.05. There was no relationship was observed between CBC parameters with duration of disease and age ,P.value>0.3. There was relationship observed between the duration of disease with history of blood transfusion and complication P.value0.023. No correlation between WBC,s count,Platelets count,Hemoglobin concentration and duration of disease among SLE(P = 0.66 , .11, . 35, R = .062, -.226, -.134 respectively). This study concluded that there was significant decrease in Hb, RBCs count, PCV, MCH , Neutrophils , Eosinophils and Basophils differential count between Systemic Lupus Erythromatosus patients and control group.