Evaluation of Prothrombin Time, Activated Partial Thromboplastin Time, and Platelets count among Alcohol Consumers – Khartoum 2014

Abstract

The study is analytical case control study, conducted in Khartoum during period from May to August 2014. The study aimed to evaluate prothrombin time,Activated partial thromboplastin time, and platelet count among alcohol consumers. The evaluation of PT, PTT, and platelet count of blood coagulation were determined on one hundred willing by volunteered subjects. Fifty (50) of them served as cases (alcohol consumer) all of them are males with variable duration of drinking habit. Most of them (62%) are primary, (30%) are secondary, and (8%) university according to education level. And fifty (50) were grouped as control (non alcohol consumer). Most of them(according to education level) are study university (78%). The age group of all subjects ranged between 20 to 70 years. 5.7 ml of fresh venous blood were collected for each individual in plastic containers, 3.0 ml in EDTA and 2.7 ml in trisodium citrate for anticoagulant. Then the contents of the containers (2.7 ml trisodium citrate) were mixed and centrifuged at 3000 round/min for 15 minutes for preparation of platelets poor plasma (PPP). The PPP were tested for PT and PTT using the coagulometer (COATRON M1). The remaining 3.0 ml EDTA blood containers tested for platelet count using automated hematology analyzer (sysmex). The results were analyzed by independent T test of the SPSS computer programme. The results of cases revealed that PT was 16.6 /seconds, APT Twas 32.7/seconds, and Plts count was 272/cumm. The results of control group that PT was 13.6/seconds, APTT was 31.1/seconds, and Plts count was 263/cumm. The results were showed significant increased in PT when compared with control group with P.value < 0.05 and no significant variation were noticed in both APTT and Plts count.