Association Between Estradiol and Lipid Profile in Sudanese Women with Breast Cancer

Abstract

Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. Epidemiological and experimental evidence implicates estrogen and lipid profile in the etiology of breast cancer. This study was carried out to determine the association between the estradiol and lipid profile in breast cancer women. In this study 90 women including 50 breast cancer patients (24 -75 years) age matched with 40 non cancerous women then divided to premenopause and posmenopause. Early morning blood samples collected from participant were assessed for lipid profile photometricly and estradiol by ELISA technique and SPSS computer program used for data analysis. There was a significant increase in total Cholesterol (TC) (p <0.001), triglyceride (TG) (p < 0.005), low density lipoprotein (p < 0.001) and Body Mass Index (BMI) (p < 0.05) in the breast cancer patients compared to the controls group. With the exception of estradiol that decreased, the lipid profile increased with age in both patients and controls with a much higher value in patients than controls group. Also BMI, TG and LDL-cholesterol increased significantly in patients than controls group during premenopausal stage. However TC is significantly raised during both pre and postmenopausal stages. Also there was significant negative correlation between LDL-cholesterol and estradiol. This study suggested that there was an association between estradiol, lipid profile and BMI and increase risk of breast cancer.