Seroprevalenceof Cytomegalovirus Infection among Blood Donors in Khartoum State

Abstract

This study was conducted during the period from March to May 2014. The aim of this study was to determine the seroprevalence of Human Cytomegalovirus (HCMV) among blood donors attending Blood Bank department at National Public health Laboratory and Blood Bank department at Khartoum Teaching Hospital. A total of 100 subjects (n = 100) were included in the study. The blood donors ages range from 15 to60and from both genders. From the study participants, serum sample were obtained and personal and clinical data were collected , sera were tested for CMV IgM and IgG antibody using Enzyme Linked Immuno Sorbent Assay (ELISA). Out of the 100 blood donors tested, 73 % and 19 % were CMV IgG and CMV IgM positive, respectively, subjects were divided in two age groups (<30 years and ≥ 30 years ) in order to evaluate the effect of age on CMV seropositivity from the above finding we concluded that, there was no significant difference (p > 0.05) between the two age groups on CMV IgG and IgM seropositivity . Also we concluded that there was high percentage of human cytomegalovirus HCMV among blood donors, and there was no significance difference (p > 0.05) between both history of previous surgical operation and blood transfusion and CMV seropositivity . Since about19 % of blood donors are seropositive for CMV IgM , it would be very useful to screen blood donors for CMV to identify the CMV- seronegative blood donors, and maintain an inventory of them for use as donors, in which recent studies revealed that the virus can transmit even after using universal leucoreduced blood product.