Abstract:
This is a descriptive retrospective study carried out in Ribat university hospital, Soba university hospital and the Medical military hospital during the period from January to June 2014. This study aimed to determine of the expression of Ki67 and Her2 in cervical tumors.
Forty five samples were randomly selected from patients with cervical tumors, patients identification data were obtained from files records. Most patients in our study were between 27 year and 85 year, there were 18 (40%) patients were in less than 50 year and 27 (60%) patients were in more than 50 year. We find 10 (22%) samples were benign tumors while 35 (78%) samples were malignant tumors. The malignant tumors included 29(83%) samples were squamous cell carcinoma and remaining 6.0 (17%) samples were adenocarcinoma. From this samples 14 (31%) samples were Ki67 positive and 31 (69%) samples were Ki67 negative , also the results showed 15 (33%) samples Her2 positive and 30 (67%) samples were Her2 negative by using immunohistochemical technique, all positive samples were malignant tumors, 14 (40%) samples were Ki67 positive and 15 (43%) samples were Ki67 negative this sample were squamous cell carcinoma and no result found of Ki67 expression for adenocarcinoma and there were 10 (29%) samples Her2 positive while 19 (54%) samples were Her2 negative this result in squamous cell carcinoma and there were 5.0 (14%) samples Her2 positive and 1.0 (3.0%) samples Her2 negative in adenocarcinoma, and there were no any expression of Ki67 and Her2 in benign tumors, this result means Ki67 and Her2 expression offered significant different between Ki67 and Her2 and cervical tumors and significant different between Ki67 and Her2 expression with the type of malignant tumors and also found the significant different between Ki67 and histopathological grade while there were no significant different between Her2 expression and the histopathological grade.
