Evaluation of Microalbuminuria and Plasma Creatinine in Type -2 Diabetes Mellitus Patients - White Nile State - Sudan

Abstract

Descriptive cross-sectional hospital based study was conducted in Kosti Diabetic Centre, White Nile state during the period from March 2013 to August 2013. In order to assess microalbuminuria and serum creatinine levels in Sudanese patients with type2 diabetes mellitus , ninety subjects were enrolled in this study, fifty subject clinically confirmed diabetic patients and forty apparently healthy persons as control group. Microalbuminuria and hemoglobin A1C were estimated using NycoCard READER2 urine-albumin sandwich ELISA kits, creatinine was estimated using alkaline picrate method, fully automated analyzer used for washing and reading processes when microalbuminuria and hemoglobinA1C estimated, spectrophotometer analyzer for reading of creatinine and glucose concentration, questioner and results data obtained were analyzed using (SPSS version 16). Our study found increase in mean of microalbuminuria level among patients compared with control group resulting in (P-value=0.002). This study showed significant increase in mean of hemoglobinA1C levels in case group in comparison with control group resulting in (P-value=0.000). Results showed increase in mean of serum creatinine levels in case group compared with control group (P-value=0.005). Also our study results showed medium positive correlation between microalbuminuria and duration of the disease. The study concludes increase in microalbuminuria level among Sudanese patients with diabetes mellitus especially who had long duration. Microalbuminuria, creatinine and hemoglobinA1C measured regularly to evaluate if diabetic patients in Sudan and monitoring to avoid renal problems is recommended.