Chemical Characterization and Biological Activity of Flavonoids in Some Medicinal Plants

Abstract

In this study Three plants species from eastern and western Sudan were studied: Namely Acacia nubica benth( Laot), Citrus paradisi (grapefruit ) and Combretum Hartmonnina Schweinf (Habeel ). The plant material was extracted using 95% ethanol.The crude extracts were subjected to a phytochemical screening which revealed the presence of flavonoids among other phytochemicals .The crude extracts were purified by thin layer chromatography utilizing different solvent systems ,and characterized using : IR,UV,1HNMR and Mass spectroscopy . Aflalavonoid :7,5´,6´- trihydroxy-5-methyl-isoflavone was isolated from the bark of Combretum Hartmonnina Schweinf (Habeel ), 5,7,4´,5´-tetrahydroxy-6,8,1´,2´,6´-pentamethoxyflavanone was isolated from the leaves of Acacia nubica and7-oglycosyl-5,4´ - dihydroxyflavanone was isolated from the leaves of Citrus paradise. The isolated flavonoids revealed promising antimicrobial potential.