Abstract:
High titers of antibodies to anti thyrotropin receptor(TRA-Ab), and
Thyroperoxidase antibodies(TPO-Ab) are the hallmarks of human autoimmune
thyroid diseases. The aim of this study was to assess the antibodies in Sudanese
hyperthyroidism (mean age 33.22±10.04, range 19-59 years) with
hyperthyroidism and graves' disease. One hundred Sudanese patients with
hyperthyroidism(50with hyperthyroidism and clinically diagnosed with graves'
disease, 50 with hyperthyroidism and clinically diagnosed without graves'
disease), and fifty apparently healthy as control group , age and sex were
matched. Study done in Endocrinology Outpatient Clinic at Omdurman
Teaching Hospital, Khartoum state, Sudan, during the period June 2011 to
June 2013.
Thyroid function test ( FT3, FT4, and TSH) was determined by using fully
automated chemical analyzer (ROCH ELECSYS ) with COBAS kits, and anti
Thyroperoxidase antibodies, and anti thyrotropin receptor antibodies were
determined by ELISA technique with Euro immune Kits. Analysis of the data
was performed using the SPSS , P < 0.05 considered significant.
Study showed that there were significantly high serum FT3, anti TRA, TPO
antibodies among the Sudanese patients with Graves disease compared with
patients with hyperthyroidism. 90% of patients with graves' disease had
positive TRA antibodies, and 16% had positive TPO antibodies.
In conclusion, the parameters, FT3, anti-TRA- Ab, and anti-TPO-Ab can be
used as a biochemical panel for differential diagnosis of Graves' disease from
hyperthyroidism.
