Estimation of Prothrombin Time, Activated Partial Thromboplastin Time and Fibrinogen Level among Type II Diabetes Mellitus and Hypertension Patients in Khartoum State

Abstract

This was a descriptive analytical cross-sectional conducted in Khartoum state during the period from March to April 2014. The aim of this study was compare theprothrombin time, activated Partial thromboplastin time andfibrinogen level betweentype II diabeticpatients, hypertensive patient, patients had both disease and control group.A total of 120 consecutive persons were enrolled; 30 patients withdiabetestype II. Next 30 patients with diabetes mellitus type II pulse hypertension. Next 30 patients with hypertension and 30 samples from healthy individual (control group). Samples were collected in 3.2% tri-sodium citrate. Coagulation profile was estimated by using coagulometer. The mean of age in patients with diabetes type II (53.3 ± 13.6 years), patients with hypertension (58.3 ± 13.4 years), patients with diabetes pulse hypertension (57.2 ± 11.0years) and control group (45.13 ±7.7 years). PT was significantly increased in diabetictype II (14.103 ± 1.1) and hypertensive (14.5 ± 1.9) patientscompared with control group (13.367±1.2 seconds)(Pvalue0.011)and insignificantly different betweenpatients with diabetes type II pulse hypertension(13.283±1.5seconds) and control group(13.367±1.2seconds) (P value 0.813)and significantly decrease in patients with diabetes type II pulse hypertension compared to who had only hypertension or only diabetes. APTT was significantly increased in diabetictype II(37.937± 6.2seconds)and patients with both diseases(38.423± 6.7seconds) compared with control group (29.867± 4.3seconds)(P value 0.000), and insignificantlydifferent between hypertensive patients (29.767± 5.2seconds) and control group (29.867± 4.3seconds) (P value 0.936)and significantly increase in patients with diabetes type II pulse hypertension compared to who had only hypertension or only diabetes.Fibrinogen level wassignificantly increased in diabetictype II (314.67 ± 92.8mg\dl) and patients with diabetes pulse hypertension (362.67 ± 115.4mg\dl)compared with control group (225.7 ± 34.1mg\dl) (P value 0.000) and statistically insignificant difference between hypertensive patients (240.67± 51.9 mg\dl) and control group (225.7 ± 34.1mg\dl) (P value 0.192)and significantly increase in patients with diabetes type II pulse hypertension compared to who had only hypertension or only diabetes.This results analyzed by SPSS version 14. In conclusion fibrinogen was significantly increased in patients withdiabetes pulse hypertension compared topatients with hypertension or patients with diabetestype II so measurement of fibrinogen level, PT and APTT may be predictor forthrombosis which may lead to complicateof hypertension and type II diabetes mellitus.