Synthesis, Evaluation and Application of Radioiodine Labeled Compounds in Nuclear Medicine

Abstract

This study reviews synthesis, evaluation, diagnostic and therapeutic applications of iodine radiopharmaceuticals especially with 131I and 123I in contemporary nuclear medicine. It is well known that iodine is used in thyroid diagnostic and therapy with sodium iodide and played an important role in diagnostic procedures using single photon emission tomography (SPECT). The study covers the general chemistry of iodine, physical properties, biological role of iodine, general uses of iodine compounds, production and decay schemes of 131I, 125I and 123I in the first chapter. Preparation of radioiodine labeled compounds, quality control of radiopharmaceuticals and safety of radioiodination are dealt with in detail in two chapters. These were followed by chapters dealing in length with the chemistry, preparation, quality control, pharmacokinetics and radiation dosimetry of Some iodine radiopharmaceuticals, and then current trends in diagnostic and therapeutic applications of iodine radiopharmaceuticals particularly 131/123I-MIBG and 123I-IMP. We found that the iodine radiopharmaceuticals are considered amongst principal indicators in single photon emission tomography (SPECT), and 131/123I-MIBG and 123I-IMP appear to be appropriate diagnostic and therapeutic agents for variety of diseases.