Seroprevalence of Celiac Disease among type 1 Diabetes Mellitus in Wad Medani Paediatric Teaching Hospital

Abstract

The aim of this study was to determine the seroprevalence of celiac disease (CD) among type 1 diabetic children. Across sectional hospital based study was carried out in integrated management of diabetic children at Wad medani paediatric teaching hospital. From October 2008 to February 2009, 145 patients with type 1 diabetes, 66 males (aged 3 to 19 years) and 79 females (aged 5 to 19 years), were screened for CD using anti-tissue transglutaminase antibody (t-TGA) determined by ELISA. Clinical data, hemoglobin Alc, insulin requirements were evaluated. Nine (6.2%) patients were positive for (t-TGA) giving a prevalence of CD in diabetic children of 2.9%. The prevalence of CD was found higher than expected. The females were more affected by CD than males. Serologic markers for CD are useful for identifying asymptomatic type 1 diabetes children who should undergo intestinal biopsy.