Estimation of Incidence of Autoimmune Hemolytic Anemia, among Chronic Lymphocytic Leukemic patients in Khartoum State

Abstract

This is descriptive and cross-sectional study aimed to detect autoimmune hemolytic anemia among chronic lymphocytic leukemia (CLL) Sudanese patients in Khartoum state during the period from March to Augusts 2012. A total fifty Sudanese fulfill diagnosed with CLL were enrolled in this study, 34 (68%) males and 16 (32%) females, their age ranged from 41 to 80 years, and twenty healthy individuals of the same age were selected as control group. Five ml EDTA anticoagulated blood sample was collected from each patient and investigated using direct antiglobulin test (Coomb̕̕ s test), complete blood count, comment on peripheral blood picture and reticulocyte count, The Direct antiglobulin test was positive in 4 (8%) cases and negative in 46 (92%). Blood film showed different degrees of spherocytosis and reticulocytosis, which enforce our point of view. The mean hemoglobin concentration and reticulocyte count was 10.6 g/dl and 2 % respectively with highest value 10%. Autoimmune hemolytic anemia was present in both sexes in our study. Autoimmune hemolytic occur in CLL Sudanese patient above 50 years age.