Correction of splitted Radiotherapy Course for Cancer Patients

Abstract

The study aim of this study was to correct the skipped radiotherapy course for cancer patients. It has been carried out in 50 patients presented with common types of cancers in RICK hospital, the data collected including diagnosis, total dose, daily dose fraction, number of fraction, number of given fraction, total bio-effect, given bio-effect, decay factor, final bio-effect, missing bio-effect and rest period. The collected data has been analyzed by using Exile software and it reveals that: radiation bio-effect increases as the tumor dose TD increases according to y = 0.0153x + 19.203 with significance at R2 = 0.6. And the the decay factor decrease as the rest period increases according to y = 0.018x + 0.8372. at R2 = 0.9. The radiation bio-effect% increases with TD increment for total biological effect and the final biological effects according to y= 0.0153x + 19.203 and y = 0.0153x + 19.203 and significance at R2 = 0.6 and 0.7 respectively. The final radiation bio-effect due to splitted radiotherapy course was 75.1% and the missing biological effect was 40.8%. Also the analysis showed that the missing biological effect was so significant in affecting tumor control at t = 0.5 (t-test).