Assessment of Ovarian Tumor Maker CA 125 During Radiotherapy Radiotherapy Course

Abstract

The aim of this study is to assess the tumor marker CA-125 level during radiotherapy course as well as to obtain other objectives such as the correlation between the age and ovarian cancer, stage of ovarian cancer versus tumor marker CA-125 and to show whether the ovarian cancer is predominant among obese patients or not?. The study was carried out in RICK – RIA lab and the analyzed data showed that: the common involved age by ovarian carcinoma was the age group of 30-40 years old taking a percent of 68 relative to other ages groups, and the age group of 40-50 years old was also showed considerable incidence scoring 16%. And the correlation of A125 versus age was so insignificant (R2 = 0.00) before radiotherapy course, while after radiotherapy course the result showed less significant effect of aging in the level of A125 U\ml (R2 = 0.42) with minor decreasing influence of aging in the level of A125 and the correlation could be given by the following equation: ‫ 8.6 + ݔ30.0− = ݕ‬where y refers to level of A125 U/ml and x refers to age in years. The result also showed that the average of A125 before radiotherapy was 134 ± St. D. 13.3 U/ml relative to 5.5 ± St. D. 2.1 U/ml after radiotherapy i.e. there was 128.5 U/ml of A125 difference which is equivalent to 367.1% relative to normal level of A125 (35 U/ml). Also the tumor marker CA-125 increases as the cancer stage goes to advance one and for stage I, II, III and IV the average level of A125 was 41.1, 55.6, 82.5 and 143.8 U/ml respectively with a significant correlation coefficient at (R2 = 0.98). The measurement of obesity based on BMI showed that the average BMI of the patients was 28.2 indicating that most of the patients were obese i.e. carrying the risk factor of ovarian carcinogenesis.