Serum lipid profile in Sudanese Patients with Chronic Renal Failure

Abstract

A cross-sectional study conducted during the period of December 2008 to March 2009, compared the serum levels of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol of 50 patients with chronic renal failure (as a test group) and 30 apparently healthy volunteers (as a control group). All patients and controls were from Ibn Sena Hospital, Kartoum, Sudan.The test group and the control group was matched in terms of age and gender. The serum levels of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol were measured using Selectra E/vital lab from Linear .Company, Spain The data was analyzed and the results showed the top cause of chronic renal failure in this study was diabetus mellitus (42%) and most of patients .were in the age group 20-40 years The serum levels of triglucerides and creatinine were significantly increased in the test group compared to the control group (P<0.05), while the serum levels of the total cholesterol, HDL-cholesterol and LDL-cholesterol were not significantly different in the test group compared to the control .(group (P>0.05 In patients with chronic renal failure, the serum levels of triglycerides and total cholesterol were positively correlated while the serum levels of HDL-cholesterol were negatively with the duration of the disease and there is no correlation between serum levels of LDL-cholesterol with the duration of chronic renal failure and no correlation was found between the serum .levels of creatinine and the serum levels of triglycerides or total cholesterol From this study, it is concluded that, in Sudanese patients with chronic renal failure, the serum levels of triglycerides are raised, but the serum levels of total cholesterol, HDL-cholesterol and LDL-cholesterol are not affected. The duration of the disease has a weak positive correlation with both the serum levels of triglycerides and the serum levels of total cholesterol, and has no correlation with the serum levels of LDL-cholesterol, but has a weak negative correlation with the serum levels of HDL-cholesterol. The serum level of creatinine has no correlation with neither total cholesterol nor .triglycerides