Thyroid Stimulating Hormone among Sudanese Women with Polycystic Ovary Syndrome, A pilot Study in Khartoum.

Abstract

Infertility frequently present in both women with polycystic ovary syndrome (PCOS) and subjects with thyroid dysfunction. This study aimed to determine the variation of thyroid-stimulating hormone (TSH) level among PCOS patients. One hundred participants; fifty women were diagnosed as PCOS and 50 without P COS were enrolled in this cross-sectional comparative study, during the period from June to November 2019. Serum TSH, total triiodothyronine hormone (TT3) and total thyroxin hormone (TT4) levels were measured using enzyme-linked immunosorbent assay (Cobas-e-411), while anti mullerian hormone (AMH) was determined using ultrasensitive method by Electrochemiluminesent (ECL) immunoassay (Roche’s e411), and results statistics were computed using SPSS 20. The mean age of PCOS group was (26.08 ±3.92) and non-PCOS group (25.8 ± 3.91) years. Bilateral cyst in the ovary and irregular menstrual cycle were predominant among PCOS women. A significant increased mean of TSH among PCOS women occur when compared to non-PCOS P.value <0.05. A significant positive correlation between TSH and body mass index (BMI) in PCOS women P. value <0.05, r= 0.3. In conclusion study results revealed that PCOS status was associated with increased TSH level that considered an indicator to subclinical hypothyroidism among Sudanese women with PCOS.