Antimicrobial Activity of Solenostemma argel and Cymbopogon proximus Against Carbapenem Resistant Gram Negative Bacteria Isolated from Different Hospitals in Khartoum State

Abstract

Use of plant based drugs and chemicals for curing various ailments as old as human civilization. Plants and plant-based medicaments are the basis of many of the modern pharmaceuticals we use today for our various ailments. Cymbopogon proximus and Solenostemma argel from medicinal plant which widely used especially in Sudan. The study was aimed to investigate the antimicrobial activity of ethanolic extract of Solenostemma argel and Cymbopogon proximus against carbapenem resistant bacteria during the period from February 2018 to December 2018. Agar disc diffusion method was used to determine the antimicrobial activity of of Solenostemma argel and Cymbopogon proximus, the ethanolic extract was examined against carbapenem resistant Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis and Klebsiella pneumoniae isolated from different hospitals in Khartoum State from urine, wound swab, blood and body fluid from 80 clinical isolates. The ethanolic leaves extract of Cymbopogon proximus show activity against tested bacteria , the activity reach to (76%),at high concentration decrease by low concentration, gave best result with Proteus mirabilis(87.5) then Escherichia coli (80.9%), Klebsiella pneumonia(75%) and Pseudomonas aeruginosa (61.5%). And Solenostemma argel less in activity just gave (12%). Ethanol extract of Cymbopogon proximus was found to be effective as antibacterial against bacteria under test, providing the scientific basis for its traditional application in Sudanese folk medicine against many bacterial diseases, extract had an in vitro antibacterial activity against carbapenem resistant bacteria, and Ethanol extract Solenostemma argel poor in activity further studies are required to confirm this result to identify active ingredient and toxicity