Evaluation Of The Impact Of Cigarette Smoking On Platelets Parameters Among Sudanese Males In Khartoum State

Abstract

This is analytical cross sectional study conducted in Khartoum state during the period from March 2019 to February 2020 to evaluate the effect of cigarette smoking on platelet count and indices on Sudanese males. Materials and methods:Fifty (50) samples were collected from smokers and fifty (50) samples were collected from non-smokers as control, all participants were informed about the study and informed consent for participation was obtained. The age of smokers between eighteen (18) and sixty (60) years and consume one cigarette per day, and not suffer from bleeding, diabetes mellitus or hypertension. Three millimeters venous blood samples were collected in ethylene diamine tetra acetic acid (EDTA) containers. The platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW) were investigated using haematological analyzer (sysmex KX-21N) and obtain data by (SPSS) computer program version 20 was used for data analysis. Results:The result of this study revealed that was significant decrease in PLT count (Mean ± SD 216.1 ± 67.9, P.value =0.01), and significant decrease in PCT (Mean ± SD 205.5 ± 59.2, P.value=0.04) and MPV (Mean ± SD 11.0 ± 9.6, P.value=0.21) in the smokers when comparing to nonsmokers (Mean ± SD 245.8 ± 47.5), (Mean ± SD 226.5 ± 45.2), (Mean ± SD 9.3 ± 1.2) respectively. While PDW (P.value=0.23) showed no significant difference between smokers and non-smokers (Mean ± SD 13.1 ± 3.0) ((Mean ± SD 13.8 ± 2.5) respectively. This decrease was related to the number of cigarettes per day and intensity of smoking but not related to the age. Conclusion:There is statistical decrease in platelet count, PCT and MPV among cigarette smokers when compared with nonsmokers. PDW show no differences between smokers and nonsmokers.