Assessment of Serum Levels of Total Testosterone Among Sudanese Male With Type Two Diabetes Mellitus In Khartoum State

Abstract

Type 2 diabetes is associated with an increased fat mass (in particular central adiposity), reduced insulin sensitivity, impaired glucose tolerance, elevated triglycerides and cholesterol and low HDL-cholesterol. All these factors may be lead to secondary hypogonadism in men and reduced total testosterone level in blood. This cross-sectional study was carried out to investigate the level of total testosterone among Sudanese male with type 2 diabetes mellitus in Khartoum state. Fifty blood samples were collected from diabetic's male (type2) as case group and fifty blood samples were collected from non diabetic's male as control group from Khartoum state during the period from February to September 2018.All blood samples were collected in two containers which one is plain container and the serum are separated after clot formation for The estimation of serum total testosterone which was done by using automated hormone analyzer (tosoh analyzer),and another containers is EDATA the whole blood was used to estimate HbA1c by clover A1Canalyzer, then the results was analyzed by using SPSS computer program. Statistical analysis showed a significant decrease in serum total testosterone level in male with type 2diabets mellitus (mean ± SD: 4.62 ± 0.88ng/ml) when compared to control (6.35 ± 0.67ng/ml) with p. value= 0.000. Results showed there was negative correlation between age of diabetic's males and serum total testosterone level (R= -0.614, P=0.000) ,also there was negative correlation between body mass index of diabetic's males and serum total testosterone level (R= -0.375, P=0.007), also there was strong negative correlation between HbA1c of diabetic's male and serum testosterone level (R= -0.710, P=0.000) , finally there no correlation between duration of diabetes and serum total testosterone level( R= -0.180,P=0.211). . In conclusion: diabetic's males with type 2 had decreased total testosterone levels which negatively correlated with age, BMI and HbA1c