Assessment of Total Plasma 25-OH Vitamin D Level, and its Association with Bone Mineral Density Among Post-Menopausal Sudanese Women

Abstract

Background: The post-menopausal stage in the women consider critical phase which effect bone mineral density. The loss of bone density in postmenopausal women has been linked to a subclinical deficiency in vitamin D. The aim of this study to assess of total 25-OH vitamin D level, and bone mineral density among postmenopausal Sudanese women. Methodology: This study included 87 post-menopausal women age varying from (40- 80 years); DXA scan (reading T-score) was used to determine bone mineral density (Normal, osteopenia and osteoporosis ). plasma total 25(OH) vitamin D was estimated by using Fortress kit and ELIZA technique. The data was analyzed by used SPSS version 19. Result: This study showed according to bone mineral density (BMD) (Normal 33, osteopenia39 and osteoporosis 15), vitmin D level (Insufficient 7, Deficiency 46, and sever deficiency 34). Significant decrease in mean of vitamin D levels in postmenopausal women when compared with reference range P-value (0.00). Insignificant changed in vit-D level when compared BMD groups, significant decrease in mean of BMD T score when compared with vit-D group P-value (0.01), and no Correlation between BMD and Vit D. Conclusion: Our study conclude that Postmenopausal Sudanese women had a decrease in plasma total 25 OH vitamin D level, and osteopenia had most common among post-menopausal Sudanese women.