Assessment of Changes in Coagulation Profile and Platelets Count in Sudanese Patients with Hypothyroidism and Hyperthyroidism in Khartoum State

Abstract

Thyroid hormones have a crucial role in metabolism , Thyroid dysfunction induces different effect on coagulation system and platelet count . . This was retrospective analytical case control study was conducted at the Radiation Isotope center in Khartoum state during the period of August to December 2019,aimed to investigate the association between thyroid disease and changes in coagulation profile and platelet count . The study populations were 33 patients with hypothyroidism, 17patients with hyperthyroidism and 50 healthy volunteers as control matched age and sex .5 ml of blood was collected from all participants automated blood coagulation analyzer was used for measuring activated partial thromboplastin time (APTT)and prothrombin time (PT)and. APTT value was significantly lower (p value less than .05) in patients with hyperthyroidism (26.52 sec) than in control group (32.43 sec). Hypothyroidism patients showed APTT values (33.66 sec), PT valuesin both patients with hypo thyroidism (10.77second )and hyperthyroidism (11.28 sec)were significantly lower (p value 0.00) than that of the control group(13.79 sec) . Hypothyroid patients show a significantly( p value less than 0.05) higher reduction in PT value than hyperthyroid patients. Sysmex hematological autoanalyzer used for measured of total platelet count . Data were analyzed by SPSS computer soft program version 20 , this study included 10% male and 90% female. No significant variation was observed in platelet count among the study population. Hypothyroidism(256),hyperthyroidism (267),and platelet counts in control group was (252). In conclusion; both hypothyroidism and hyperthyroidism were associated with significant abnormalities in some coagulation parameters. So coagulation profile in patients with thyroidism must be evaluated routinely to avoid their complications.