Assessment of Serum Testosterone and Low density Lipoprotein levels among Males Hypertensive Patients

Abstract

Background: Hypertension is a serious public health concern. More than one-quarter of the adult population over the world has hypertension, a significant health burden in many countries. Objectives: To assess serum testosterone and low density lipoprotein cholesterol levels among males Hypertensive patients in Khartoum state. Methods: This was a case control study was conducted at Khartoum state during the period from April to December 2019 . It was aimed hypertensive male of different Sudanese ethnic groups. The over all number of participants was 80 male, 40 males as hypertensive patients and 40 male normal subjects serve as control, the mean of age among case was 54 years and 51 years among control group. Testosterone tested by Automated immunoassay Tosoh, AIA 360 and low density lipoproteins cholesterol tested by Bio system, Data was collected using a questionnaire and analysis was done by statistical package of social since (SPSS) software. Results: There was significant decreased of testosterone in male hypertensive patients when compared with male control group (p. value 0.000 ) and mean SD in male hypertensive patients 4.03± 0.75 and in male control group 6.1 ± 0.46 , and low density lipoproteins cholesterol was significantly higher in the hypertensive groups than control (P.value 0.040) and mean SD in male hypertensive patients 2.44 ± 0.24 and mean SD in male control group 2.34 ± 0.16. There were significant decrease of testosterone related to age and duration of disease , There was negative correlation related to age (p.value 0.030 R -0.725), duration of disease ( p.value 0.035 R -0.334) and testosterone ,There was no correlation related between low density lipoprotein cholesterol and age (p.value 0.085 R 0.600) ,duration of disease ( p.value 0.198 R 0.22) and diastolic blood pressure ( p.value 0.29 R 0.171) and there was negative correlation related between low density lipoproteins cholesterol and systolic blood pressure (p.value -0.085 R0.005) . Testosterone level was positive correlation related to systolic blood pressure ( p.value 0.290 R 0.016) and diastolic blood pressure (p.value 0.375 R0.017) . Conclusion: This study concludes that the male hypertensive patients had lower testosterone and higher low density lipoprotein levels