Assessment of Lipids Profile among Sudanese Patients With Chronic Renal Failure Under Heamodialysis in North Kordfan State

Abstract

Background:. Renal failure is a condition in which the kidneys fail to remove metabolic end-products from the blood and regulate the fluid, electrolyte, and pH balance of the extracellular fluids. Dyslipidemias is a very common complication of Chronic Renal Failure (CRF). Objective:This study done to assess the lipid profile among end stage renal disease under heamodialysis. Material and method: This study include 100 participants (50 patients on heamodialysis and 50 controls) was carried out in Elobeid Teaching Hospital Aljmeih Renal center) during September 2019 to December 2019. Three ml of blood was taken from each volunteerson lithium heparin to prepare plasma,the plasma was used to measure total cholesterol,triglycerides,high density lipoprotein and low density lipoprotein, using spectrophotometer (semi automation instrument),and results were analyzed using statistical package for social science (SPSSversion21). Result: The result shows significant increase of total cholesterol, LDL-C and Triglyceride in pre heamodialysis versus control group while HDL-C (mean±SD): insignificantly decrease 159.52±44.62versus 127.00±38.78mg/dl, P- value=0.000(TC) 78.02±32.64 versus 61.20±20.51mg/dl and p- value 0.003(LDL-C) 151.16±49.73 versus106±25.88,P-value 0.000(TG) . 42.92±9.74 versus 47.18±12.30mg/dl,P value0.004, ( HDL-C), Also The result show significant increase of total cholesterol, LDL-C and Triglyceride in postheamodialysis versus control group while HDL-C (mean±SD): insignificantly decrease (159.52±38.75 versus127.0025.28 mg/dl ,p-value0.000 ( TC) .(71.38±31.85 versus 61.20±20.51mg/dl, p-value 0.060)LDL-C ,(196.54±72.63 versus 106.56±25.8mg\dl8, p –value0.000).TG (45.74±12.85, versus47.18±12.30 mg/dl P- value0.005 )HDL-C Also result show there was significant increase in TG and effect in HDL-C , LDL-c and cholesterol in postheamodialysis compare to pre heamodialysis mean ±SD ,(42.92±9.74 versus 45.74±12.85 mg\dl,and p-value0.029 ) (HDL-C ,(151.16+-49.73 versus196.54 ±72.63 mg\dl ,p value=0.000).TG (159.52±44.64 versus 159.52±38.78mg/dl ,p-value1.000)(TC) ,(78.02±32.64 versus71.3831.85 mg\dl ,p-value =0.138) LDL-C Result also showed no correlations between T.cholesterol, HDL-C, LDL-C and Triglyceride in preheamodialysis and duration of disease. (r=0.032, p=0.2). TC (r=-0.08 ,p=0.5). HDL-C (r=0.15 , p=0.29). LDL-C (r=-0.06 ,p=0.60). TG Result also Shows no correlations between T.cholesterol, HDL-C, LDL-C and Triglyceride in post heamodialysis and duration of disease (r=0.1, p=0.40). TC (r=-0.22 ,p=0.4). HDL-C (r=0.25 , p=0.07). LDL -C (r=-0.13 ,p=0.36).TG Result also showed significant increase in TG\HDL-c ratio in casegroup compare to control group and before and after dialysis. 3.85±2.53 p-value 0.04 (pre heamodialysis) 4.64±2.38 p-value0.001 (post heamdialysis) 3.8±2.53 ,4.6±3.38 .P-value= 0.00). in post heamdialysis compared to pre heamodialysis. Conclusion: From this study it can be concluded that plasma (TC, LDL and TG were significant rise in pre and post heamodialysis patients compared to control Also showed TG\HDL-C ratio increasedin case group compare to control group and postheamodialysis compared to pre heamodialysis patients.