Synthesis, Characterization and Biological activity of Some Amino Acid and Mixed Amino Acid Complexes with Some Transition Metals

Abstract

Fourteen Amino acid complexes, eight complexes [M(L)2]Cl type of Co (II) ion with glycine, serine, arginine, aspartic acid, Cu (II) and Fe (III) ions with glycine, Zn (II) ion with cysteine, and Ni (II) ion with leucine, five mixed amino acid complexes [M(L)(Lʹ)]Cl type of Au (III) ion with (glycine+ asparagine) , and (Serine+ Cysteine), Fe (III) ion with (Arg+Asp), Ni (II) ion with (cysteine+leucine), and Zn (II) ion with (asparagine+lucien), and one mixed amino acid complex [M(L)(Lʹ)(Lʹʹ)] type of Fe(III) ion (Arg +Asp+Ser), have been synthesized and characterized using EDX, FTIR, UV/Vis, TGA, XRD, spectra and conductivity measurements. All amino acid ligands with metal ions have been found to act as bidentate chelating agents coordinating through COO- and NH2, to form octahedral geometry for Co (II), Cu (II), Ni (II) and Fe (III) complexes, squire planer geometry for gold (III) complexes, tetrahedral geometry for Zn (II) complexes. The antibacterial activity of amino acid complexes were evaluated against five bacterial strains, three kinds of Gram positive (Staphylo coccus aureas, Entero coccus feacalis, Klebsiella pneumonia), and two kinds of Gram negative (Escherichia coli, Pseudomonas aeruginosa). The metal ions complexes were found to have good and varied degree of inhibitory effect against test bacteria.