Assessment of Serum Calcium, Albumin and Phosphorus Levels among Female Patients with Polycystic Ovarian Syndrome in Sudan

Abstract

Background: polycystic ovarian syndrome (PCOS) is a condition affects 5% ---10% of women of reproductive age worldwide. Characterized by increased ovarian and adrenal androgen secretion. Metabolism of calcium is regulated by vitaminD and Ca with vitamin D have direct effect on the ovarian and/or adrenal steroidgenesis pathway, Albumin is carrier of calcium in the blood and phosphorus metabolism also regulated by vitamin D Objective: This study was carried out to assess serum level of calcium, albumin, and phosphorus in Sudanese female patients with polycystic ovarian syndrome Material and Methods: hundred women are involved in this study divided to Fifty newly diagnosed PCOS subjects aged 19-40 years and fifty age-matched healthy women as control group. 3 ml venous blood collected into plain container from each volunteer under aseptic condition. All blood samples were allowed to clot at room temperature, and then there were centrifuged at 4000rpm to obtain serum, serum obtain was used to analysis calcium, phosphorus and albumin by using urit8021A fully auto analyzer. And the result obtain where analyzed by using statistic package for social science (SPSS) version20 on programmed computer. Results: The mean level of serum calcium was significantly decreased in patients with polycystic ovarian syndrome in comparison with control group (8.714±1.1646)mg/dl versus (9.220±1.5260)mg/dl with p-value 0.031. In contrast the mean of serum phosphorus was insignificant different in patients with polycystic ovarian syndrome in comparison with control group (4.324±0.7925)mg/dl versus (4.076±0.8923)mg/dl with p-value0.133. On the other hand the mean level of albumin were insignificant different in patients with polycystic ovarian syndrome in comparison with control group (3.812±.6123)g/dl versus (4.050±.6594)g/dl with p-value0.068. Person’s correlation showed, serum calcium inversely correlated with BMI of PCOS patient(r=-0.355,p- value0.011). Conclusion: The study concluded that serum calcium is lower among PCOS patient while Albumin and phosphorus is insignificant changed.