Serum Total Protein, Albumin, C-reactive protein, Magnesium Levels, Aspartate Aminotransferase and Alanine Aminotransferase activity among Sudanese Male Cigarette Smokers in Khartoum State

Abstract

Background and Aim: Cigarette smoking is one of the 10 greatest contributors to global death and disease. Cigarette contains harmful chemicals such as carcinogenic, cytotoxic and free radicals, which are affect many organs. The aim of this study was to evaluate the levels of serum total protein, albumin, C-reactive protein, magnesium, and aspartate aminotransferase, alanine aminotransferase activity among men smokers at Khartoum- state. Method: The study was analytical cross sectional case control,100 individuals were enrolled as study group (50 cigarette smokers and 50 nonsmoker). Blood samples were drown from both groups to measure serum total proteins, albumin, magnesium levels and aspartate aminotransferase(AST), alanine aminotransferase(ALT) activity by Mindary BS-200, C-reactive protein (CRP) by i-Chroma. Data were analyzed by statistical package for social science (SPSS-16). Result: Serum aspartate aminotransferase, alanine aminotransferase activity and C-reactive protein levels were significantly higher in cigarette smokers group versus non smokers group with (mean ±SD) for AST( 25.4 ± 6.50 IU/L VS 16.9 ± 5.16 IU/L,P.V=0.00),ALT was(24.1 ± 6.99 IU/L VS 14.2 ± 5.52 IU/L ,P.V=0.00) and CRP was (4.04 ± 1.65 mg/L VS 2.85 ± 1.06 mg/L, P.V=0.00). While Serum total protein, albumin and magnesium levels were significantly lower in cigarette smokers group versus non smokers with (mean ±SD) for T.P( 6.26 ± 0.45 g/dL VS 7.26 ± 0.69g/dL,P.V=0.00), albumin was (3.86± 0.59 g/dL VS 4.96 ± 0.45 g/dL, P.V=0.00), magnesium was(1.76 ± 0.27mg/dL VS 2.39 ± 0.36 mg/dL, P.V=0.00). Conclusion: Smokers had significant increased in serum alanine aminotransferase, aspartate aminotransferase activity and C-reactive protein level ,and significant decreased in serum total protein, albumin and magnesium levels