Chemical Constituents of Some Phytochemicals From Ammomum sublatum, Foeniculum vulgare and Psidium guajava and their Biological Activity

Abstract

Extraction of the fruit of Amomum sublatum with 90% ethanol gave a crude product , which was fractionated over silica gel plates to afford a chromatographically pure flavonoid- compound I. The structure of the isolated flavonoid was partially elucidated by spectral tools (UV and H1NMR) and the following partial structure was proposed: Compound I The aqueous extract of Ammomum sublatum was assessed for antimicrobial activity against five standard bacteria. It showed significant activity against the bacterial strains : Pseudomonas aeruginosa and Bacillus subtilis . It also showed good anticandidal activity The oils from Foeniculum vulgae and Psidium guajava were studied by GC-MS , furthermore the oils have been assessed for antimicrobial activity. The GC-MS analysis of Foeniculum vulgae oil revealed the presence of 32 components. Foeniculum vulgae oil showed excellent activity against Staphylococcus aureus in the concentration range : O C CH3 O O C CH3 CH3 CH3 V 100-25mg/ml. It also exhibited significant activity against the yeast Candida albicans at 100mg/ml. GC-MS analysis of Psidium guajava oil revealed the presence of 30 constituents. The oil showed activity against all test organisms,but it was partially active against the fungus Candida albicans. Significant activity against Staphylococcus aureus was observed.