Evaluation of Thyroid Stimulating Hormone, Thyroxine and Triiodothyronine in Post-menopausal Women with Osteoporosis

Abstract

Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture incidence. The osteoporosis is becoming public health problem in Sudan and neighboring countries and worldwide. Thyroid hormones and TSH are necessary to normal development and function of human skeleton, it increase bone turnover when bone resorption exceeding formation. The skeleton is exquisitely sensitive to thyroid hormones and TSH, which have profound effects on bone development, linear growth, and bone maintenance. This is the cross sectional case control study carried out in a period from April to October (2018) in Khartoum, Sudan. The study was conduct on 100 post -menopausal women, 50 with osteoporosis as case, and 50 without osteoporosis as control. Women were enrolled in the study after taking their verbal consent, to evaluate thyroid hormones and thyroid stimulating hormone level. Venous blood (3ml) was collected from the participants in Heparin containers and gently mixed. Thyroid hormones and TSH level were determined by Enzyme-Linked Immune Sorbent Assay technique. The obtained data were analyzed by both Student's Independent samples T test and person correlation test using SPSS version 20 computer program. By analysis of the result, noticed that the insignificant association (no differences) p. value more than 0.05 between case and control group regarding Thyroid stimulating hormone, Thyroxine, body mass index, age and Triiodothyronine We also observed insignificant correlation between Body mass index & TSH, BMI & T3 and BMI and T4, in addition to insignificant correlation between TSH with T3 & T4. In conclusion thyroid hormones and TSH is normal in studied groups.