Estimation of Antithrombin III Level in Patients with Deep Venous Thrombosis in Khartoum State

Abstract

This is case control study carried at in Bahri teaching hospital, outpatient clinic, Khartoum state, at Sudan University Science and Technology. The aim of this study was to estimate of Antithrombin III level among DVT patients. Sixty individual were enrolled, 30 with DVT patients and 30 healthy volunteers were included as control group. Fourteen (46.7%) of patients with DVT were males, while 16(53.3%) of patients were females. Fifteen (50%) of control group were males, while 15 (50%) of control group were females, the selection patients and control group from different Sudanese tribes. Citrated venous blood sample 2.7 ml was collected with drawn from participant, and using ACCENT 200 Antithrombin III Kit and explore their relation with hypercoagulable state. The results were analyzed by statistical package of social science (SPSS). The results showed a significant decrease in Antithrombin III level in patients with DVT compared with control group, and Pregnant women also had significantly lower Antithrombin III levels compared to non pregnant women (P. value < 0.05). There was no statistically significant correlation between Antithrombin III levels an obesity, gender, contraceptive use and age (P. value > 0.05). In conclusion, Antithrombin III level found to be lower in DVT patients.