Assessment of Plasma Levels of Cholesterol, Triglycerides, LDL-C and HDL-C among Sudanese Menopausal Females in Khartoum State

Abstract

After menopause, there is loss of ovarian function. This results in adverse changes in glucose and insulin metabolism, body fat distribution, coagulation, fibrinolysis and vascular endothelial dysfunction. This study was carried out to assess plasma; levels of cholesterol, triglycerides, LDL-C and HDL-C among Sudanese menopausal females in Khartoum state. A total of 94 participants were included in this study Forty seven were menopause women age range from 48-70 years as case group and forty seven of them were from pre menopause woman age range from 25-47 years as control group from Khartoum state during the period from April to August 2018. The estimation of serum lipid profile was done by using bio systems BTS-305 then results were analyzed by using SPSS computer program. Statistical analysis showed a significant increase in plasma cholesterol level in menopause (mean±SD: 245.1±32.0 mg/dl) when compared to control (175.9±40.5 mg/dl) P-value = 0.000, a significant increase in plasma triglycerides level in menopause (mean±SD: 142.7±31.3 mg/dl) when compared to control (87.40±41.1 mg/dl ) P-value =0.000, a significant increase in plasma LDL-C level in menopause (mean±SD) (171.2±31.3 mg/dl) when compared to control (159.1±30.6 mg/dl) P-value = 0.000, a significant decrease in plasma HDL-C level in menopause (mean±SD) (40.72±11.9 mg/dl ) when compared to control (52.04±10.1 mg/dl mg/dl) P-value = 0.044. statistical analysis also showed a significant increase in plasma cholesterol and LDL-C according to duration of menopause, for cholesterol: (mean±SD) (233.8±25.7) (239.6±25.9) (267.2±37.4) P-value=0.009, a significant increase in plasma LDL-C (153.9±44.53) (177.7±31.24) (185.2±35.78) P-value = 0.034, insignificant difference in plasma level of triglycerides and HDL-C in were found across difference age group according to duration of menopause, for triglycerides (mean±SD) (135.8±32.5) (145.8±30.6) (147.6±31.3) p-value = 0.526, for HDL-C (mean±SD) (36.94±6.49) (42.47±16.94) (43.38±8.90) P=0.256 according to duration of menopause from (1-5), (7-12), (>12) year respectively. Results showed positive correlation between age of menopause and plasma cholesterol level (R=0.463, P-value =0.001), no correlation between age of menopause and plasma triglycerides level (R=0.186, P-value =0.210), plasma HDL-C level (R=0.220, P-value =0.137), plasma LDL-C level (R=0.206, P-value =0.165), In conclusion: menopause women had increased level total cholesterol, triglyceride, low density lipoprotein, and the level of cholesterol, LDL-C was increased according to duration of menopause. Moreover a proportional correlation is noted between age of menopause and cholesterol level.