Assessment of Liver Functions in Sudanese with Long Standing Type2 Diabetes Mellitus

Abstract

A case-control study conducted during the period from January 2011 to December 2012, compared the plasma levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, bilirubin, total protein, albumin and HbA1c of 200 Sudanese patients with long standing Type2 diabetes mellitus ( as a test group) and 100 apparently healthy volunteers (as a control group).Participants in this study were from Jaber Abu Elez diabetic center in Khartoum state, Sudan. Age and sex of the test group were matched with the control group. The plasma levels of ALT, AST, ALP, bilirubin, total protein, albumin and HbA1c were measured using a semi automated methods. The means of the plasma levels of ALT, AST, ALP, bilirubin and HbA1c% of the diabetic group were significantly raised when compared to the control group. The means of the plasma levels of total protein and albumin of the diabetic group were significantly reduced when compared to the control group. In the diabetic group the plasma levels of ALT, AST, ALP and bilirubin show positive correlations with duration of diabetes,HbA1c and BMI, whereas the plasma level of total protein and albumin shows negative correlation with the duration of diabetes , ,HbA 1c and BMI. From the results of this study, it is concluded that: in Sudanese patients, type2 diabetes mellitus is associated with high plasma levels of ALT, AST, ALP and bilirubin and low levels of total protein and albumin. In addition, there are positive correlation between the plasma levels of ALT, AST, ALP and bilirubin with the duration of diabetes, HbA 1c and BMI. And negative correlation between plasma levels of total protein and albumin with duration of diabetes, HbA1c and BMI.