Evaluation of Testosterone Hormone Level in Healthy Obese Subjects in Khartoum State

Abstract

Back ground: Obesity is a state of excess adipose tissue, associated with abnormal sex steroids concentrations which are related to the degree of obesity. This study was carried out to assess serum level of testosterone hormone in obese subjects. Material and methods: fifty samples were collected from obese and overweight (male and female) in period between August to November 2017, chosen randomly in Khartoum State, and 50 apparently healthy individuals with normal BMI as control group, to assess the effect of obesity on testosterone hormone level. Estimation of serum testosterone level was done by using enzyme immune assay analyzer (TOSOH), and results were analyzed using Statistical Package of Social Science (SPSS) computer program. Result: The result of this study showed that the mean concentration of testosterone hormone in obese subjects was significantly decreased compared to control (Mean ± SD for cases versus control). (Mean ± SD: 4.25±1.97 versus 9.97±10.74, P. value=0.003). It showed that the mean concentration of testosterone in obese male was significantly decreased compared to control male (4.17 ± 1.05 versus 22.05 ± 6.34, P.value =0.00). In addition it showed that mean concentration of testosterone in obese female was significantly increased compared to control (4.70±2.97 versus 1.92 ± 0.89, P.value =0.00). Also showed that mean concentration of testosterone in obese class 1 was significantly increased compared to control (3.95±1.89 versus 9.97±10.74, P. value=0.008). It showed strong positive correlation between BMI and Testosterone in obese female(r=0.5, p=0.03). Conclusion: It is concluded that the serum level of testosterone hormone decreases in Sudanese obese male but increases in obese female.