Evaluation of The Impact of Tobacco Smoking on Platelets Parameters in Khartoum State

Abstract

Tobacco smoking use is widely spread throughout the world. Tobacco smoking has been claimed to cause a wide variety of health problems such as atherosclerosis, mutagenesis of exposed cells and cancer. the effect of smoking on human health are serious and in many cases deadly, the present study was cross sectional did to investigate the effect of cigarette smoking on platelet parameters in male smokers.The study was carried out on fifty Sudanese male smokers.Who smoked at least 10 cigarettes per day for at least one year. Their age ranged 17-70 years. Control(non-smokers) group was collected with the same range of age for statistical comparison. the smokers divided into sub groups according to the number of cigarette per day (10−19)(20−30), the effect of number of cigarette per day investigated and show positive correlation with PLT count, MPV, PDW P.value and R.valuerespictively were (P.value=0.000),(R.value=0.842),(P.value=0.000),(R.value=0.847),(P.value=0.000)(R.value=0.555), while it had negative correlation with PCT(P.value=0.000)(R.value= −0.796). The result revealed that a significant increase in PLT count, PDW and significant decreased in PCT in smokers while MPV did not show significant difference between smokers and non – smokers P.value respictively(P.value=0.015),(P.value=0.000),(P.value=0.007),(P.value=0.292 ) mean±SDrespictively; 245.62±73.29 , 14.41±1.51 , 0.17±0.09 , 9.96±1.13 while in non smokers group; 217.02±36.90 , 12.43±1.94 , 0.21±0.06 , 9.73±0.92 . More ever the age had effect on that parameters .it had negative correlation with PCT, PDW(P.value=0.000)(R.value= −0.414)(P.value=0.002)(R.value= −0.305)respictively while PLT count, MPV did not effected by age. The effect of back/years on PLT values was also investigated and show possitive correlation with PLT count,MPV, PDW P.value and R.value respictively(P.value=0.000)(R.value=0.912),(P.value=0.000)(R.value=0.870),(P.value=0.000)(R.value=0.575) while it had negative correlation with PCT.Also the type of smoking had effect on the PLT parameters, it effects only on PCT value while other parameters did not effect.