Estradiol and calcium levels among Female patients with Polycystic Ovarian Syndrome in Khartoum State

Abstract

Background: Polycystic ovarian syndrome is associated with increased ovarian and adrenal androgen secretions and hyperandrogenism and resultant hirsutism, hyperinsulinemia and central obesity. Although vitamin D primarily plays a role in bone metabolism, it has important functions in the reproductive system. Vitamin D receptors are found in ovarian and endometrial tissues and play an important role in steroidogenesis. Vitamin D deficiency is more frequently encountered in patients with polycystic ovarian syndrome. Objective: This study was carried out to assess the level of calcium, albumin, AMH and estradiol in female patients with polycystic ovarian syndrome. Material and Methods: forty newly diagnosed PCOS subjects aged 18-35 years and 40age-matched healthy women as control group at Khartoum state. Results: The mean level of plasma calcium was significantly decreased (p.value 0.000) whereas the mean level of AMH was significantly increased (p. value0.000) in patients with polycystic ovarian syndrome as compared to control group. On the other hand the mean level of estradiol and albumin were insignificantly decreased (p.value 0.086 and 0.283) respectively. In conclusion polycystic ovarian syndrome decreases the level of calcium, estradiol and increases the level of AMH.